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recR [2018-07-17 19:07:49]
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recR [2018-07-17 19:07:49]

required for the formation of RecA DNA repair centers
locus
BSU00210
pI
5.30
mw
21.83 kDa
protein length
198 aa Sequence Blast
gene length
594 bp Sequence Blast
function
DNA repair/ recombination
product
formation of RecA DNA repair centers
essential
no
synonyms
recM
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.5|DNA repair/ recombination]
  • [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.5|DNA repair/ recombination] → [category|SW 3.1.5.6|Other proteins]

    • Gene

    Coordinates
    28,867 → 29,463

    Phenotypes of a mutant

  • drastically reduced survival of mature dormant spores after exposure to ultrahigh vacuum desiccation and ionizing radiation that induce single strand (ss) DNA nicks and double-strand breaks (DSBs) [Pubmed|24285298]

    • The protein

    Catalyzed reaction/ biological activity

  • required for the formation of [protein|A44D4677FB70BE8F554BF1001A500F817C7DA95F|RecA] DNA repair centers (together with [protein|80E6F156764FF30300D034EE6FB44F2DB8338AF3|RecO]) [Pubmed|24891441]

    • Protein family

  • recR family (according to Swiss-Prot)

    • [SW|Domains]

  • [SW|TOPRIM domain] (aa 80-175) [Pubmed|9722641]

    • Structure

  • [PDB|2V1C] (the [protein|BEBAF1EB53EBB3E7558BB5FE73C418B50000FA29|RecR]-[protein|80E6F156764FF30300D034EE6FB44F2DB8338AF3|RecO] complex from ''Deinococcus radiodurans'', [protein|BEBAF1EB53EBB3E7558BB5FE73C418B50000FA29|RecR]: 52% identity, 78% similarity, [protein|80E6F156764FF30300D034EE6FB44F2DB8338AF3|RecO]: 30%/ 58%) [Pubmed|17581636]

    • [SW|Localization]

  • cytoplasm (homogeneous) [Pubmed|16479537]

    • Expression and Regulation

    Operons

    genes
    [gene|73D063EDC412F7F28DA27C986ECCCD1C4A1F6618|dnaX]-[gene|9AFCEFE83560B1E2B1FFD7CFD2E4F17FAE137889|yaaK]-[gene|BEBAF1EB53EBB3E7558BB5FE73C418B50000FA29|recR]-[gene|C5127208E7562F09249112240F0BE8C582B2E5AD|yaaL]-[gene|CB5D3A2E5BEE336539BEB2D7C5D9C3A63C78FD01|bofA]
    description
    [Pubmed|22383849]
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    Biological materials

    Mutant

  • BKE00210 (Δ[gene|BEBAF1EB53EBB3E7558BB5FE73C418B50000FA29|recR]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE00210 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGTTCTTTTATCCCCCTA, downstream forward: _UP4_TTGTAAGGAGGAAAAAGCGA
  • BKK00210 (Δ[gene|BEBAF1EB53EBB3E7558BB5FE73C418B50000FA29|recR]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK00210 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGTTCTTTTATCCCCCTA, downstream forward: _UP4_TTGTAAGGAGGAAAAAGCGA

    • References

    Reviews

  • 22933559

    • Original publications

  • 12884008,17581636,16479537,24285298,24285298,24891441,9157236,9108290,8419343,9722641